Modeling of identity - by - descent processes along a chromosome between 3 haplotypes and their genotyped ancestors
نویسندگان
چکیده
1 2 Modeling of identity-by-descent processes along a chromosome between 3 haplotypes and their genotyped ancestors 4 5 T. Druet,* and F. Farnir 6 *Unit of Animal Genomics, Faculty of Veterinary Medicine and Centre for Biomedical 7 Integrative Genoproteomics 8 Unit of Animal Productions, Faculty of Veterinary Medicine, University of Liège, B-4000 9 Liège, Belgium 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Genetics: Published Articles Ahead of Print, published on March 24, 2011 as 10.1534/genetics.111.127720
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Modeling of identity-by-descent processes along a chromosome between haplotypes and their genotyped ancestors.
Identity-by-descent probabilities are important for many applications in genetics. Here we propose a method for modeling the transmission of the haplotypes from the closest genotyped relatives along an entire chromosome. The method relies on a hidden Markov model where hidden states correspond to the set of all possible origins of a haplotype within a given pedigree. Initial state probabilities...
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